Articles Tagged With:
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Do We Overdiagnose Breast Cancer in Women 70 Years and Older?
Overdiagnosis of breast cancer from mammography is common in women age 70 years and older and increases with age. The use of mammography in women older than age 70 years does not reduce breast cancer deaths.
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How Many Steps a Day Will Improve Patients’ Longevity?
A systematic review and meta-analysis of studies of the association of step counts and cadence with all-cause mortality and cardiovascular events showed the benefits in these outcomes are statistically significant, at about 2,600 steps/day and peak at about 8,000 steps/day. Also, faster step cadence augments these benefits.
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Subcutaneous Furosemide Infusion Device
A small patient-applied infuser pump for a pH neutral formulation of furosemide has been developed. A comparison of an intravenous (IV) bolus of furosemide to a five-hour infusion with the pump has been completed and shows that the device is well tolerated and provides similar bioavailability as IV furosemide.
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Upgrading Prior Right Ventricular Pacing in Heart Failure
A randomized, controlled, open-label study of upgrading patients with right ventricular pacemaker-induced left ventricular dysfunction and heart failure to cardiac resynchronization pacing plus an implantable cardioverter defibrillator (ICD) has shown reduced heart failure hospitalization and improvements in left ventricular function compared to ICD placement alone.
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Apixaban Dose in Atrial Fibrillation Patients with Chronic Kidney Disease
A large nationwide health systems database study comparing 5 mg apixaban vs. 2.5 mg twice daily in patients with stage 4/5 chronic kidney disease not on dialysis shows that the 5 mg dose increases the risk of bleeding compared to 2.5 mg without any improvement in the risk of stroke, systemic emboli, or death.
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The Natural History of Aortic Stenosis Revisited
A large multi-institution observational study of patients referred for Doppler echocardiography to assess for aortic stenosis has shown that discrepant measurements are not uncommon. When four-year all-cause untreated mortality is considered, the intermediate grades of aortic stenosis behave like the next highest level stenosis, which suggests that we should consider intervening earlier in moderate to severe stenosis.
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Five-Year TAVR vs. SAVR Data Show Encouraging Results, but Do Not Move the Needle for Clinical Decision-Making
The PARTNER 3 trial randomized low-risk patients to transcatheter aortic valve replacement vs. surgical aortic valve replacement. Five-year data show no significant differences in the composite endpoint of death, stroke, or rehospitalization.
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Superinfection of Hepatitis B and Hepatitis D on the Horizon
Called a satellite virus, hepatitis delta virus (HDV) is making an outsized impact on liver disease and cancer worldwide. HDV only appears alongside a hepatitis B infection, and people living with HIV infection are particularly at risk of the disease.
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Clinicians Should Develop Sexual Health Screening Soft Skills
At a time when STIs are on the rise, all providers need to develop skills in sexual health screening. New research shows these skills are lacking among many physicians, and there are other barriers to screening patients for STI risk factors.
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Time of Day Affects the Probability of Antibiotic Initiation for Hospitalized Patients with Sepsis
In this retrospective cohort study of patients with hospital-onset sepsis, the probability of antibiotic initiation was lowest at shift changes and gradually declined overnight compared to during the day shift.